When do peptides begin aggregating during chemical synthesis?
A peptide chain begins to clump when it is about five to eight amino acids long during synthesis. Depending on the sequence and synthesis conditions, this can happen at any point in the peptide. Aggregation of chains presents a major challenge since they cannot properly react with amino acids once clumped. The phenomenon occurs through hydrogen bonding and hydrophobic interactions between growing peptide chains attached … Continue reading When do peptides begin aggregating during chemical synthesis?
